Accentrate® Chewable Softgel is now available!

MZI™

MZI™ is a mineral capsule that contains bioavailable forms of Magnesium, Zinc, and Iron that do not cause gastrointestinal issues. The capsules may be opened and the contents mixed with food-it is mostly tasteless. MZI™ is different than Accentrate® because it doesn’t have the omega-3s and vitamins–only the minerals.

MZI™ is intended to either be taken with Accentrate®, and is substantially discounted (45% off) when purchased together, or as a standalone for those looking to add mineral supplementation to their stimulant regime.

Magnesium, Zinc & Iron

Magnesium deficiency has been shown to be in in 72% of ADHD children
Iron deficiency has been reported in children with cognitive and behavioral impairments that prominently include poor attention and hyperactivity
Magnesium and zinc are key nutrients and co-factors that plays an important role in the formation of neurotransmitters dopamine, norepinephrine, and serotonin.

Correct your body’s chemistry TODAY!

Why MZI™

Magnesium deficiency has been shown to be in in 72% of ADHD children¹ and individuals with ADHD are likely to be deficient in zinc.² Iron deficiency has been reported in children with cognitive and behavioral impairments that prominently include poor attention and hyperactivity.³^,⁴

Magnesium and zinc are key nutrients and co-factors that plays an important role in the formation of neurotransmitters dopamine, norepinephrine, and serotonin. Dopamine is important for attention and serotonin is important for regulating mood. Iron is a cofactor for enzymes necessary for the synthesis and catabolism of the monoaminergic neurotransmitters,⁵which are strongly implicated in the etiopathophysiology of ADHD.⁶

Restoration

AccentrateMZI™ provides minerals that are known to be deficient in individuals with ADHD.⁷ The minerals in AccentrateMZI™ are provided in chelated form that break down in the stomach to provide better absorption and increased bioavailability. Chelated minerals are a safe, effective and well-tolerated form that should not result in constipation, nausea, diarrhea, or gastric upset. These minerals have important roles in neurologic function, including involvement in neurotransmitter synthesis.

Research

Stimulant medication has been shown to cause magnesium deficiencies that may increase irritability, anxiety, agitation, insomnia, facial tics, and nail-biting. Magnesium supplementation may improve these conditions. Low levels of zinc have been shown to impede the effectiveness of stimulant medication.⁸ And zinc supplementation has been shown to increase the effectiveness of stimulant medication. It has also been suggested that iron supplementation could be considered as an important adjunctive therapy to strengthen the effectiveness of psychostimulants rather than as a treatment per se for ADHD.⁹

*To see the full list of referenced studies.

These statements have not been evaluated by the Food and Drug Administration (FDA). This product is not intended to diagnose, treat, cure, or prevent any disease.

Patience

Studies have shown that magnesium supplementation in ADHD patients for at least 2 months resulted in improved clinical symptoms including reduced hyperactivity and aggressiveness, additionally, school attention improved. When the magnesium treatment was stopped, clinical symptoms reappeared in few weeks. It has also been reported that the Parent and Teacher Rating Scale scores improved with zinc supplementation over a 6-week, double blind, and placebo-controlled trial.¹⁰ Supplementation with zinc has also shown to improve symptoms of hyperactivity, inattentiveness, and oppositional behavior.¹¹

Scientific References

Baza, et. al., “Magnesium Supplementation in Children with Attention-Deficit/Hyperactivity Disorder,” The Egyptian Journal of Medical Human Genetics, (2016) 17, 63-70.
Toren, et. al. “Zinc deficiency in attention-deficit hyperactivity disorder,” Biological Psychiatry, Vol. 40, Issue 12, 1308-1310.
Lozoff, et. al., “Long-lasting neural and behavioral effects of iron deficiency in infancy.” Nutr. Rev. (2006) 64, S34–S43.
Konofal, et. al, “Iron deficiency in children with attention-deficit/hyperactivity disorder,” Arch Pediatr Adolesc Med, 2004; 158: 1113-5.
Youdim, et. al.“The neurochemical basis of cognitive deficits induced by brain iron deficiency: involvement of dopamine–opiate system.” Cell. Mol. Biol. (Noisy-le-Grand) (2000) 46(3), 491–500.
Biederman, et. al. “Attention-deficit hyperactivity disorder.” Lancet (2005) 366(9481), 237–248.
Villagomez, et. al., “Iron, Magnesium, Vitamin D, and Zinc Deficiencies in Children Presenting with Symptoms of Attention-Deficit Hyperactivity Disorder,” Children, 2014, 1: 261-279.
Arnold, et. al., “Does Hair Zinc Predict Amphetamine Improvement of Add/Hyperactivity?,” International Journal of Neuroscience, 1990: 50:1-2, 103-107.
Cortese, et. al. “Iron and attention deficit/hyperactivity disorder: what is the empirical evidence so far? A systemic review of the literature,” Expert Review of Neurotherapeutics, (2012)12(10), 1227–1240.
Akhondzadeh, et al., “Zinc sulfate as an adjunct to methylphenidate for the treatment of attention deficit hyperactivity disorder in children: A double blind and randomized trial,” BMC Psychiatry, 2004, 4:9.
Uçkardeş, et. al., “Effects of zinc supplementation on parent and teacher behaviour rating scores in low socioeconomic level Turkish primary school children,” Acta Paediatr. 2009 Apr; 98 (4): 731-6.

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