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How AccentrateTM works

AccentrateTM contains omega-3 fatty acids, which address lipid imbalances associated with ADHD, as well as vitamins and minerals, which the body uses to support proper regulation of neurotransmitters needed for optimal cognition, including memory, attention, and focus.

The research behind lipid imbalances

The u-3 polyunsaturated fatty acid (PUFA) docosahexaenoic acid (DHA) and, to a lesser extent, the u-6 PUFA arachidonic acid (AA) constitute a large proportion of the lipid in the brain. The u-3 PUFAs DHA and eicosapentaenoic acid (EPA) are involved in many aspects of brain function including cell growth, neural signaling, and gene expression.[1]

Omega-3 PUFAs are thought to play an important role in cell membrane elasticity and myelination and may thus affect neural signal transduction. Animal studies indicated that omega-3 PUFA deficiency, and specifically DHA deficiency, results in decreased neuron size in rats that were raised on a DHA-deficient diet. Furthermore, both dopaminergic and serotonergic neurotransmission have been shown to be reduced in rats on an omega-3 PUFA-deficient diet, with marked effects in the frontal cortex.[2]

More specifically, lower frontal cortical omega-3 PUFA status correlated with hyperactive and impulsive behavior in rats. Interestingly enough, a vast body of human literature has implied neurotransmitter dysfunction and impairments in cognitive control for those suffering from ADHD. With all this in mind, this may suggest a potential target for omega-3 supplementation in the treatment of this disorder. [3]

It’s also been shown that people diagnosed with ADHD are more likely to have low levels of certain lipids, specifically certain omega-3 fatty acids. ADHD has been shown to be associated with metabolic disturbances in lipid metabolism[4]. The imbalances in lipid metabolism that may occur in ADHD are associated with increased oxidative stress, higher rates of lipid degradation, and decreased synthesis of phospholipids containing omega-3 fatty acids. Reduced levels of phospholipid-EPA and phospholipid-DHA affect membrane structure and function.

AccentrateTM promotes optimal neurotransmitter regulation

Signal transduction and receptor signaling are major membrane functions which may be influenced by membrane stability and fluidity. Lower concentration of omega-3 LCPUFA in neuronal tissue has been speculated to lead to lower serotonin levels at critical periods of neurodevelopment and may result in a cascade of suboptimal development of neurotransmitter systems limiting regulation of the limbic system by the frontal cortex, thus explaining the association to oppositional behavior.” [5]

AccentrateTM was specifically formulated to include ingredients backed by scientific research

AccentrateTM contains premium ingredients that are not often found in an over-the-counter multivitamin. The ingredients are the active, bioavailable forms that cross the blood-brain barrier, which is why we call it Brain ReadyTM Nutrition. Each ingredient is also backed by the scientific literature.

AccentrateTM is More

It has been reported that “single-nutrient studies [of ADHD] have yielded only modest findings, whereas broader interventions may be more promising… A consideration of some of the ingredients and the role they play in brain metabolism highlights the importance of the broad array of nutrients and may help explain the non-specific effects the nutrients appear to have on psychiatric symptoms.” [10]

Tissue-Targeted EPA and DHA

Tissue-TargetedTM EPA and DHA are omega-3 fatty acids conjugated to a phospholipid (PL).

EPA and DHA in this form, unlike fish oil, readily bypass the blood brain barrier and are absorbed by brain tissue through Lyso-phosphatidylcholine.

“Omega-3 fatty acids play a very important role during brain development, partly through their regulation of the serotonin system. Reduced intake of EPA and DHA during neurodevelopment results in decreased serotonin synthesis, storage, release, and receptor function.” [1]

It has been reported that the developmental difficulties associated with ADHD have a neurological basis and might be related to low levels of omega-3 polyunsaturated fatty acids (PUFA), [2], [3] and some evidence reports that children with ADHD and dyslexia may show improvements in symptoms following supplementations with omega-3 fatty acids. [4]

It has been proposed that EPA regulates serotonin release and that this omega-3 fatty acid modulates serotonin function through regulation of serotonin release in the presynaptic neuron. [5]

It has also been proposed that DHA regulates serotonin receptor function and that omega-3 fatty acids modulate the serotonin system through DHA mediated regulation of serotonin receptor function, which depends on cell membrane fluidity. DHA is the most abundant fatty acid in the brain, making up 30% of the fatty acid content. [6] Cell membrane fluidity depends on the amount of omega-3 fatty acids in the membrane and phospholipids, which increase membrane fluidity. DHA composition in the lipid membrane is necessary for adequate membrane fluidity (167–170). [7] [8]

It has also been suggested that “increased u-3 PUFA intake can improve attention, literacy, and behavior problems in some children with ADHD.” [9]

Magnesium

Many people with ADHD have been shown to have Magnesium deficiencies. [19]Magnesium is an important cofactor for the synthesis of neurotransmitters. Magnesium is a cofactor in several steps of Vitamin D biosynthesis and activation.[20] The Magnesium in AccentrateTM is provided in a form that crosses the blood-brain barrier.

These statements have not been evaluated by the Food and Drug Administration (FDA). This product is not intended to diagnose, treat, cure, or prevent any disease.

L-Methylfolate

L-METHYLFOLATE is the bioavailable form of folic acid and crosses the blood brain barrier. L-methylfolate regenerates tetrahydrobiopterin, which is essential for neurotransmitter formation. [11] L-methylfolate is necessary for proper regulation of neurotransmitters. Proper regulation of neurotransmitters is important to mood, attention, and memory.

Folates have been reported to be of fundamental importance in brain growth, differentiation, development, repair, mood, cognition, ageing, and methylation. Impaired methylation of dopamine receptors and membrane phospholipids can contribute to problems in firing of neurons and subsequently to attention disorders.

Vitamin B6 / Vitamin B12

“Vitamin B6 (pyridoxal 5’-phosphate) acts as a cofactor for the synthesis of gamma-aminobutyric acid, serotonin and dopamine.” [12] It has been reported that administration of Vitamin B6, Vitamin B12, and folate “might contribute to the positive effects … given their role in the regulation of homocysteine metabolism, mood, and neurotransmitter synthesis.[13]

Vitamin D3

“Vitamin B6 (pyridoxal 5’-phosphate) acts as a cofactor for the synthesis of gamma-aminobutyric acid, serotonin and dopamine.” [12] It has been reported that administration of Vitamin B6, Vitamin B12, and folate “might contribute to the positive  effects … given their role in the regulation of homocysteine metabolism, mood, and neurotransmitter synthesis.[13]

These statements have not been evaluated by the Food and Drug Administration (FDA). This product is not intended to diagnose, treat, cure, or prevent any disease.

Testimonials

Thank you, you’ve given my son his “life” back! I strongly recommend Accentrate to any parent who has a child with ADHD. 
 
Kassie J – June 2019

We got Accentrate with 2 Vayarin capsules left.

I can honestly say, after watching the hyperactivity come back more and more, and seeing a glimpse of possible autism, 4 days on Accentrate and all that is decreasing! AND he can swallow the pill, which took some coaching as he didn’t swallow pills prior.

I’m so glad we were able to find an alternative so quickly!  

Jill F – May 2019
Our son responded well to stimulant medicine but the side effects were problematic and we had to decrease the dose. After we started Accentrate, we observed a noticeable decrease in his side effects and more regulation during the times that his medicine was no longer active, such as in the evening and morning routines. We give him one pill every morning and evening.
Navid - May 2019
I noticed a HUGE decline in his self-regulation since not being on Accentrate! What this tells me is that Accentrate's formula absolutely contributes to my son's ability to self-regulate and focus. I really appreciate the ease of taking just one capsule as opposed to a plethora of vitamins and my son thinks the capsule smells like chocolate so he likes taking it. Highly recommend!
Lucinda - April 2019
I just wanted to thank you guys for such an awesome product. We've been giving my son Accentrate for a little over a month and a half and we we are really starting to see a big change in my son. I can only imagine it will get even better with time. You definitely have a returning customer! I promote your product to everyone that is dealing with ADHD issues and will continue to do so. Again, I couldn't thank you guys enough.
Vincent - April 2019

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