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Omega’s and Zinc

Two branches of factors including background factors and environmental factors such as lack of some micronutrients have been propounded in the pathogenesis of disease.[1]

The main treatment of ADHD is the use of stimulant drugs such as methylphenidate. However, it is important to note that patients of this disorder also lack suitable clinical response after the beginning effects of the drug. In some cases, this is related to the lack of micronutrients such as omega‑3 and zinc supplementation in diet.[2] Therefore, true treatment of the disease can create a suitable clinical response in affected children.[3] The vital role of zinc has been propounded in frequency, and it has shown a variety of signs among patients that were affected by ADHD.[4]

In a double‑blind study used zinc and placebo as complementary therapy, which at the end of the experiment confirmed zinc as the complementary therapy cure for children with ADHD disorder.[5] Another study has proven zinc has a tendency preference lonely as compared with placebo in decrease of signs of hyperactivity and being social in affected children to ADHD.[6]

Essential fatty acids, especially, omega‑3 fatty acids EPA and DHA are necessary for nerve evolution. Omega‑3 consists of two essential fatty acids which are eicosapentaenoic acid (EPA) and docosahexaenoicacid (DHA). DHA is essential for nerve evolution

One study aimed to evaluate the impact of zinc and omega‑3 supplements as adjunctive drugs in the treatment of children affected with ADHD.[7] Zinc supplementation accompanied by the main treatment significantly improves symptom of attention‑deficit disorder subtype of ADHD.[8] Additionally, omega‑3 supplementation was superior to zinc in the clinical improvement of ADHD.[9]


[1] Greenbaum LA. Micronutrient Mineral Deficiencies. Nelson Textbook of Pediatrics. 18th ed. Philadelphia: Saunders; 2007.

[2] Stettler N, Bhatia J, Parish A, Stallings V. Feeding healthy infants, children, and adolescents. Nelson Textbook of Pediatrics. 19th ed. Philadelphia, PA: Elsevier Saunders; 2011.

[3] Busch B. Polyunsaturated fatty acid supplementation for ADHD? Fishy, fascinating, and far from clear. J Dev Behav Pediatr 2007;28:139‑44.

[4] Abrams S. Zinc deficiency and supplementation in children and adolescents.

[5] Akhondzadeh S, Mohammadi MR, Khademi M. Zinc sulfate as an adjunct to methylphenidate for the treatment of attention deficit hyperactivity disorder in children: A double blind and randomized trial. BMC Psychiatry 2004;4:9.

[6] Bilichi, et al, “et al. Double‑blind, placebo‑controlled study of zinc sulfate in the treatment of attention deficit hyperactivity disorder. Prog Neuropsychopharmacol Biol Psychiatry 2004;28:181‑90.

[7] Salehi B, et al, “Omega-3 and Zinc supplementation as complementary therapies in children with attention-deficit/hyperactivity disorder.” J Res Pharm Pract 2016;5:22-6.

[8] IBID

[9] IBID

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